What is the difference between differin and adapalene




















Tretinoin is a well-researched drug, with comprehensive studies covering everything from its effectiveness as an acne and anti-aging treatment to its potential side effects, long-term benefits and mechanism of action. Our Tretinoin guide, linked below, lists many of these studies, with plenty of data on how and why tretinoin works as an acne and anti-aging medication.

On the whole, tretinoin is a safe and effective drug. Its common side effects include redness of the skin to an increase in sensitivity to sunlight. Tretinoin also has a variety of uncommon side effects that range from skin discoloration to inflammation and even blisters. And while the side effects of tretinoin can be annoying, the good news is that they typically subside within one to two weeks when managed properly, as your body becomes acclimated to the medication.

This usually lasts for the first few weeks of use, and can be treated using moisturizer, sunscreen and other skincare products. It works quickly and well, with studies showing reductions in acne lesions, wrinkles and hyperpigmentation dark spots for some people in as few as three months of use. You will also need to use tretinoin daily for several months to see results. Tretinoin creams and gels can degrade quickly in sunlight. Because of this fragility, it is recommended that you apply tretinoin cream at bedtime and do not use it at the same time as benzoyl peroxide.

All in all, tretinoin is an effective, safe medication that produces good results with the potential for few minor common side effects for users. Like tretinoin, adapalene is a retinoid. However, it has several characteristics that make it quite a unique medication when compared to tretinoin.

First, adapalene can inhibit keratinocyte differentiation , making it helpful for decreasing microcomedone formations, treating inflammation and exfoliating mature comedones. Second, adapalene has a more stable chemical structure than tretinoin, making it okay to use alongside other acne medications such as benzoyl peroxide. Studies show that adapalene is effective at treating acne. No Yes Can be used with an antibiotic? For more severe acne Yes No Side effects common Irritation, itching, scaling, pain, dryness, skin discolouration or abnormal redness at the site of application.

Slight stinging or skin pain, skin irritation or tenderness, a burning sensation, dry skin, itching. Available over the counter? Yes Yes. Related Guides Acne. Written by Steve Stoddart Published 21 Sep Find more guides. Need something else?

We stock treatments for 72 conditions. Search for a condition or treatment. Authored by. Reviewed by. Can be used with an antibiotic? For more severe acne. In general, irritation was mild, but was both more common and more severe in the tretinoin group vs. No systemic side effects were seen. Conclusions: Adapalene offers comparable efficacy to tretinoin, but is less irritating. In addition to direct irritation, these products are photosensitizers, which limit their use in the summer.

Adapalene as with all retinoids is contraindicated in pregnancy, breastfeeding, and kids below Adapalene is more effective on blackheads but frequently has a slow effect on acne. When using Differin or Epiduo, acne may get worse at first.

It may take 2 to 12 weeks before you see their full effects GoodRx. The best alternative to Differin and types of adapalene is retinol combined with niacinamide. High-quality retinol can help with blackheads, whiteheads and the prevention of red, inflamed pimples. It can also help with skin texture, adding a fresh, natural glow to the skin. The addition of niacinamide topical vitamin B3 protects the skin's natural skin barrier, reduces redness, and helps reduce acne darks spots and freckles.



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